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Examples of compounding formulas
The preparation and dispensing of the compounded treatment is done only based on a doctor's prescription. The preparation and release time is between 1 and 3 days. Crisia Pharmacy prepares and dispenses according to the prescription only compounded preparations containing the active substance, but does not reproduce drugs that have marketing authorization in Romania and are produced only by drug manufacturers.
HIDROCHINONA 5%, TRETINOIN 0.1% SI BETAMETAZONA VALERAT 0.1% 25 G CREMA DEPIGMENTANTA (FORMULA KLIGMAN)
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HYDROQUINONE 5%, TRETINOIN 0.1% AND BETAMETHASONE VALERATE 0.1% 25 G DEPIGMENTING CREAM (KLIGMAN FORMULA)

135.00lei

Depigmenting cream with hydroquinone 5%, tretinoin 0.1% and betamethasone valerate 0.1% (Kligman formula) compounded in our clean room laboratory, is mainly used for melasma, pigment spots, freckles and lentigo.

✓In the pharmaceutical compounding process, only high purity active substances are used, in compliance with the RBPF (Rules of Good Pharmaceutical Practice). The use of capsules or standardized drugs is excluded from this compounding process.

It is recommended to use a product with a high sun protection factor (SPF 50+) – applied 30 minutes before leaving the house or before sun exposure.

It is dispensed only on the basis of a medical prescription that will be uploaded at the end of the order!

Comanda acum!

PRODUCT CODE: Depigmenting cream with hydroquinone 5%, tretinoin 0.1% and betamethasone valerate 0.1% - 25 g (Kligman formula)

Pharmacological properties

One of the most used Klingman formulas in pharmaceutical practice is composed of:

  • Hydroquinone – used as a depigmentation or skin whitening or skin lightening agent 
  • Tretinoin – epidermal turnover is useful to increase hydroquinone penetration and re-epithelialization rate. It is the most potent and widely used retinoid in photoaging therapy.
  • Betamethasone valerate – used to reduce skin irritation caused by the other active substances

Warnings and precautions

The therapeutic approach must be individualized by the doctor, taking into account the severity and type of symptoms.

  • Please follow the administration recommended in the prescription!
  • Personalized treatments can be modified depending on your state of health and compliance with the treatment.
  • Do not use more product or more often than recommended.
  • This preparation was prescribed only for the current pathology.
  • Do not use it later for another condition without the doctor's consent.
  • It is recommended, during long-term treatments, a correct and complete communication with the doctor, in order to be able to change the dose according to the evolution of the disease.
  • It is not recommended to take the preparation in case of sensitivity or allergy to the active substance.
  • It is recommended to avoid sun exposure during treatment, as hydroquinone may cause photosensitivity.
  • It is recommended to use a product with a high sun protection factor (SPF 50+) – applied 30 minutes before leaving the house or before sun exposure. 
  • Use under occlusive dressing is not recommended.
  • Avoid contact with eyes or other mucous membranes.
  • Avoid using the preparation around the eye area, unless your doctor recommends it.
  • Do not use the preparation on irritated skin or any other infected or reddened area without the doctor's consent.
  • Hydroquinone can cause, in the short term, the halo effect (transient depigmentation).
  • It is recommended to apply in a thin layer, after cleaning the area beforehand. 
  • On dry or sensitive skin, a feeling of dryness and slight additional irritation may occur. This usually subsides as the skin adapts to the treatment. 
  • Do not use other preparations containing vitamin C, retinol, acids, etc., without your doctor's consent.
  • If the pigmented area is very extensive, it must be treated in different cycles. 
  • Depigmentation is not immediate, so when treatment is interrupted without the doctor's consent, melanin production resumes, and the effect obtained up to that point diminishes.
  • Tretinoin may cause redness or tingling, which should subside within 15-20 minutes. In this case, start using it gradually, a few times a week, to allow your skin to adjust.
  • The preparation does not contain synthetic dyes, stabilizers, heavy metals, propylene glycol, minerals, parabens, DEA, TEA, MEA, MIT, PEG, formaldehyde, dimethicone.
  • Keep out of the reach of children. 
  • Do not use the preparation after the expiration date.

 

Conditioning

Airless bottle

The preparation is kept at room temperature 15-25 degrees Celsius, away from sources of heat, humidity and light. 

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